Journal: BMC Complementary Medicine and Therapies
Article Title: Luteolin ameliorates rat model of metabolic syndrome-induced cardiac injury by apoptosis suppression and autophagy promotion via NR4A2/p53 regulation
doi: 10.1186/s12906-025-04749-6
Figure Lengend Snippet: Lutolin suppressed apoptosis in rats with metabolic syndrome. BCL-2 gene expression ( A ) and protein ( D ) levels, CASP-3 and CASP-9 gene expression ( B and C , respectively), and protein ( E and F , respectively) levels. *: significant difference with Controls; **: significant difference with MetS; the p -value < 0.05 was considered significant.( N = 8 per each group, for gene expression measurements, the analysis was performed with three replicates)
Article Snippet: Moreover, the levels of apoptosis markers (CASP-3, CASP-9, and Bcl-2), extracellular matrix remodeling (matrix metalloproteinase-9 [MMP-9]), autophagic proteins (SQSTM1/p62, LC3, and Beclin-1 [BECN1]), as well as interstitial fibrosis indicator (TGF-β1) were assessed using ELISA kits from MyBioSource (USA), in line with the manufacturer’s protocols.
Techniques: Expressing